Job Description

Prolaio believes that continuous learning and collaboration can make a significant difference in how heart care is administered. We are creating smarter ways to address heart disease and heart risks by integrating a connected platform enabled by smart data science to help patients access the care and attention that will inform better treatments and outcomes.

We envision a future where care teams and hospitals can be more effective, the healthcare system can be more efficient, and patients have a better care experience and more fulfilling lives.

This is precision cardiology, and we know its within reach.

What Will You Do?

The Overview

Prolaio is seeking a strategic and executionoriented Chief Information Officer (CIO) to lead the companys enterprise technology function. The CIO will be responsible for defining and executing Prolaios technology strategy, ensuring a secure, scalable, and compliant IT environment across all business operations.

This role oversees core enterprise IT functions while building the modern digital foundation required to support AIdriven analytics, decentralized clinical trials, realworld data integration, and global manufacturing operations. The CIO will play a critical role in enabling Prolaios growth through robust systems architecture, data infrastructure, and operational excellence.

In addition, the CIO serves as Prolaios executive owner of information security, risk management, and cybersecurity governance. This includes designing and leading a comprehensive security program capable of meeting CISOlevel expectations as the organization scales in a highly regulated healthcare environment.

The CIO will partner closely with the Prolaio Leadership Team and Kardigan leadership to ensure the company has the technology platforms, data pipelines, and cybersecurity posture necessary to operate safely, efficiently, and in full regulatory compliance.

The Specifics

• Enterprise IT Strategy & Governance
  • Develop and execute the enterprise IT roadmap aligned with Prolaio and Kardigan business goals.
  • Establish policies for access control, data governance, business continuity, and IT risk management.
• Technology Operations & Service Delivery
  • Oversee delivery of missioncritical IT services including helpdesk, enduser computing, HRIS, ERP/Finance systems, and communication platforms.
  • Ensure reliability and uptime targets for clinical operations and internal systems.
• Cybersecurity & Compliance Oversight
  • Ensure alignment with HIPAA, 21CFR Part11, GxP, and emerging regulatory requirements.
  • Maintain robust incident response, vulnerability management, and identity management programs.
• Lead procurement, contract negotiation, and performance management for cloud, software, and hardware vendors.
• Manage relationships with Kardigans IT teams to ensure alignment of shared systems and policies.
• Own thirdparty risk management (TPRM), including vendor security assessments, ongoing monitoring, and remediation tracking.
• Ensure security controls extend to device manufacturers, cloud providers, CRO partners, and data processors.
• Cybersecurity Strategy, Risk & Governance
  • Own Prolaios enterprise cybersecurity strategy, risk posture, and security roadmap.
  • Establish and maintain an enterprise risk management framework covering IT, product, clinical, and research environments.
  • Define risk tolerance thresholds and elevate material risks to executive leadership and the Board as appropriate.
• Build and lead a highperforming IT organization with clear roles across security, service delivery, cloud operations, and enterprise architecture.

Modern & Advanced Responsibilities (AI, Cloud, Data Infrastructure)

• AI & Data Infrastructure Enablement
  • Design and manage the infrastructure required to support AI/ML workloads, including scalable cloud environments and highperformance compute resources (HPC/GPU).
  • Support secure data movement between sensors, patient devices, trial sites, and internal systems.
• Edge & Distributed Computing for Clinical Operations
  • Implement edge computing capabilities for decentralized clinical trials, enabling lowlatency, secure data processing at the device level before synchronization to central systems.
• Zero Trust Security Architecture
  • Lead adoption of a Zero Trust security model to protect all endpointsemployee, partner, and patientfacing.
  • Partner with the CISO to defend against AIspecific threats such as model exploitation and data poisoning.
• Modernize legacy systems to support interoperability and integration with analytics and AI platforms.
• Enable nearrealtime data exchange between operational systems and the CDAOs analytics environments.
• CrossFunctional Technology Alignment
  • Maintain clear ownership lines with partners such as the CDAO (models & analytics), CPO/Engineering (product software), and Operations (manufacturing systems).
  • Ensure infrastructure scalability for global clinical trials and supply chain operations.

Why Prolaio?

• Impactful Work: You will join in the fight against heart failure (HF) and hypertrophic cardiomyopathy (HCM) with the goal of extending and saving the lives of our patients while also being at the forefront of changing the healthcare industry through technology.
• Innovative Environment: You will be part of an organization doing something thats never been done before.
• Professional Growth: You will join a growing team and have a substantial impact on our daily and future operations with the opportunity to continuously learn and grow.
• Collaborative Team: You will be part of a team of collaborative, curious, and committed individuals focused on the collective good, inclusiveness, scientific excellence, and advancing digital health for cardiology.

Who You Are?

• Bachelors degree in Computer Science, Engineering, Information Systems, or related field (Masters preferred).
• 12+ years of progressively senior IT leadership roles, ideally in biotech, medtech, or a regulated healthcare environment.
• Demonstrated experience leading enterprise IT operations, cloud infrastructure, and cybersecurity programs.
• Strong understanding of HIPAA, GxP/CSV/CSA, and data privacy regulations.
• Experience implementing Zero Trust security concepts and managing modern cloud environments (AWS/Azure/GCP).
• Proven ability to modernize enterprise systems and implement APIfirst architectures.

Additional Qualifications (Nice to Haves)

• Experience supporting AI/ML infrastructure, including GPU clusters, vector databases, or similar environments.
• Prior work with decentralized clinical trials, connected medical devices, or largescale data collection workflows.
• Experience negotiating cloud service agreements that include data protection and AIspecific considerations.

Why Youll Love Working Here

• Meaningful Compensation: Competitive salary, performance bonus, and equity so you can share in what we build.
• Great Health Coverage: Medical, dental, and vision plans with multiple options and strong company contributions.
• Flexible Spending Perks: HSA, FSA, commuter benefits, and a $1,200 annual Lifestyle Spending Account to support wellness, commuting, family needs, and more.
• Time to Recharge: Generous paid time off, sick leave, and company holidays.
• Family-First Benefits: Paid parental leave, caregiver leave, and support for growing families.
• Security & Peace of Mind: Companypaid life insurance and short and longterm disability coverage.
• Plan for the Future: 401(k) plan to help you build longterm financial security.
• Care When You Need It: Easy access to telehealth and optional supplemental coverage for lifes unexpected moments.

Starting Salary is at $254,733.00 (Exact Compensation may vary based on skills, experience, and location)

Prolaio is an Equal Opportunity Employer (EOE) that welcomes and encourages all applicants to apply regardless of age, race, color, religion, sex, sexual orientation, gender identity and/or expression, national origin, disability, veteran status, marital or parental status, ancestry, citizenship status, pregnancy or other reasons prohibited by law.

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